KLOW

KLOW is a research peptide blend combining four synthetic peptides — BPC-157, Thymosin Beta-4 Acetate, GHK-Cu, and KPV — in a single vial containing 80mg total. It expands on the GLOW formulation by adding KPV, a tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) with a distinct anti-inflammatory profile in published research. The four peptides are studied together for the convergence of their mechanisms across regeneration, vascular remodeling, matrix signaling, and inflammatory modulation.

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide derived from a partial sequence of human gastric juice protein. Research has examined its role in angiogenic pathways (including VEGF expression), nitric oxide signaling, and growth factor receptor activity. It has been investigated in animal models of tendon, ligament, muscle, and gastrointestinal tissue repair.

Thymosin Beta-4 Acetate is a naturally occurring 43-amino-acid actin-sequestering peptide present in nearly all mammalian cell types. Research has explored its role in actin polymerization dynamics, endothelial cell migration, angiogenesis, and inflammatory signaling. Studies have investigated its effects in models of dermal, cardiac, corneal, and musculoskeletal tissue repair.

GHK-Cu (Copper Tripeptide-1) is a naturally occurring tripeptide — glycyl-L-histidyl-L-lysine — complexed with copper(II). First isolated from human plasma, it has been studied for its role in copper transport, extracellular matrix protein modulation (collagen, elastin, glycosaminoglycans), antioxidant signaling, and gene expression related to tissue remodeling. Dermatological and wound-healing models are a particular focus in published literature.

KPV is a synthetic tripeptide — lysine-proline-valine — corresponding to the C-terminal fragment (residues 11-13) of α-melanocyte-stimulating hormone (α-MSH). Research has examined its anti-inflammatory activity, which appears to operate through both melanocortin-receptor-dependent and intracellular pathways. Studies have investigated its role in models of gastrointestinal inflammation, dermal inflammation, and inflammatory signaling cascades (NF-κB modulation).

Research areas exploring this combination include:

• Angiogenesis and vascular remodeling
• Extracellular matrix synthesis and turnover
• Collagen and elastin expression pathways
• Actin cytoskeletal dynamics
• Inflammatory signaling and NF-κB pathways
• Melanocortin receptor signaling
• Wound healing and tissue regeneration models
• Dermal and integumentary research
• Gastrointestinal mucosal repair models
• Musculoskeletal and connective tissue research

Product Specifications

• Peptides: BPC-157 + Thymosin Beta-4 Acetate + GHK-Cu + KPV
• Quantity: 10mg BPC-157 + 10mg Thymosin Beta-4 + 50mg GHK-Cu + 10mg KPV (80mg total per vial)
• BPC-157 sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (pentadecapeptide)
• Thymosin Beta-4: 43 amino acids, acetate salt form
• GHK-Cu: Gly-His-Lys tripeptide complexed with copper(II)
• KPV sequence: Lys-Pro-Val (α-MSH 11-13 fragment, tripeptide)
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Storage: Store at -20°C, protect from light and moisture; reconstituted solutions refrigerated

Disclaimer: This product is intended for laboratory and research purposes only. It is not a drug, food, or cosmetic, and is not intended for human or animal consumption, diagnostic use, or therapeutic application.